Paula's Choice Clinical Niacinamide 20% Treatment - Best High-Potency Treatment

Paula's Choice Clinical Niacinamide 20% Treatment
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A professional-grade, high-concentration treatment designed for those seeking the maximum potential benefits of niacinamide to address texture, firmness, and hyperpigmentation.

  • +Features an exceptionally high 20% concentration of niacinamide for maximum efficacy.
  • +Combined with vitamin C (ascorbyl glucoside) to target uneven tone and texture synergistically.
  • +Silky texture absorbs well and is effective at refining pores and improving firmness.
  • -The high potency may be too strong for sensitive skin or niacinamide beginners.
  • -Relatively small bottle size (0.67 oz) compared to other serums in its price range.
  • -Must be used cautiously when layering with other potent actives to avoid irritation.

The Paula's Choice Clinical Niacinamide 20% Treatment is a powerhouse formula for experienced skincare users looking to push their results further. Boasting a 20% concentration of niacinamide, one of the highest available, it delivers intensive action on multiple fronts. This treatment is exceptionally effective at visibly refining skin texture, minimizing enlarged pores, and improving skin firmness and elasticity. The inclusion of vitamin C in the form of ascorbyl glucoside creates a potent brightening duo that works to fade dark spots and even out overall skin tone. The formula has a smooth, slightly creamy texture that feels luxurious on the skin and absorbs without leaving a heavy residue.

It is particularly recommended for use in the evening due to its potency. While highly effective, it requires a more cautious approach. Those new to niacinamide should start with a lower concentration, and even seasoned users should introduce it gradually to monitor tolerance. For the right individual—particularly those dealing with pronounced texture issues, loss of firmness, or stubborn discoloration—this treatment can produce transformative results that lower-concentration products cannot match.

Review updated at 2025-12-02